Departments of Human Pathology and Diagnostic Pathology
Wakayama Medical University
Welcome to Home Page of Departments of Human Pathology and Diagnostic Pathology,
Wakayama Medical University
We carry out pathological diagnosis in university hospital, clinical and
basic researches and educations for students and young pathologists in
our department.
We are making pathological diagnosis for more than 20,000 cases per year including 12,000 histological diagnosis and 8,000 cytological diagnosis in our university hospital. Also more than 20 cases are autopsied per year. Based on these pathological materials, we have studied both clinical and basic researches for human diseases with outside institutes as well as other departments in our university.
Our research interests center on 1) clinicopathological characteristics of various human diseases, and 2) molecular background of structural and cellular atypia of tumors. We apply various quantitative morphological methods using fluorescence properties and pattern recognition methodologies. We have been involved in the fluorescence microscopic studies of human tumor cells. Our early investigations in this field started with cell cycle analysis of human thyroid tumors using cytofluorometry and image cytometry. This led us to develop a combined method of fluorescence digital imaging and texture analysis for studies of the nuclear DNA distribution pattern. Recently we expanded our scientific interests into molecular background of nuclear atypia in tumor cells. We employ the fluorescence immunohistochemistry, fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM) to study of chromosome territory, DNA structure, tubulin positioning for nuclear polarity and nuclear membrane proteins of tumor cells.
Area of Expertise and Interests:
A. Diagnostic pathology field:
1) Analyses of clinicopathological characteristics of various human diseases,
particularly in thyroid, genitourinary tracts and skin.
2) Pattern recognition analysis of human tumors according to algorithmic and logical
methods for histocytological findings.
B. Basic pathology field:
1) Molecular background of structural and cellular atypia of tumors.
i) morphological analysis of tumor cell nuclei related with cell cycle.
ii) analysis of nuclear membrane proteins of tumor cells.
iii) conservation and alteration of chromosome territories in tumor cell nuclei.
iv) analysis of intracellular tubulin positioning for nuclear polarity.
2) Application of digital image analysis such as texture analysis to histocytochemistry.
3) Quantitative histocytochemical analysis of using fluorescence properties.
4) In situ visualization of point mutation of human tumor cells.
STAFFS
| Professor & Chairman | Shin-ichi Murata, MD, Ph.D. |
smurata@wakayama-med.ac.jp |
| Senior Assistant Professor (Department Vice Chair) |
Fumiyoshi Kojima, MD, Ph.D. |
|
| Assistant Professor | Yuichi Takahasi, MD. | |
| Assistant Professor | Ryuta Iwamoto, MD. | |
| Assistant Professor | Yurina Mikasa, MD. | |
| Assistant Professor | Ibu Matsuzaki, MPAS. | |
| Sub-assistant Professor | Kanako Sagan, MD. | |
| Sub-assistant Professor | Mizuki Nishikawa, MD. | |
| Sub-assistant Professor | Mikako Doyama, MD | |
| Secretary | Ms. Masako Inada | w-hupath@wakayama-med.ac.jp |
OUR ACTIVITIES IN DIAGNOSTIC PATHOLOGY AND RESEARCH
We carry out pathological diagnosis in university hospital, clinical and
basic researches and educations for students and young pathologists in
our department. We are making pathological diagnosis for more than 20,000 cases per year including 12,000 histological diagnosis and 8,000 cytological diagnosis in our university hospital. Also more than 20 cases are autopsied per year. Based on these pathological materials, we have studied both clinical and basic researches for human diseases with outside institutes as well as other departments in our university.
Our research interests center on 1) clinicopathological characteristics of various human diseases, and 2) molecular background of structural and cellular atypia of tumors. We apply various quantitative morphological methods using fluorescence properties and pattern recognition methodologies. We have been involved in the fluorescence microscopic studies of human tumor cells. Our early investigations in this field started with cell cycle analysis of human thyroid tumors using cytofluorometry and image cytometry. This led us to develop a combined method of fluorescence digital imaging and texture analysis for studies of the nuclear DNA distribution pattern. Recently we expanded our scientific interests into molecular background of nuclear atypia in tumor cells. We employ the fluorescence immunohistochemistry, fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM) to study of chromosome territory, DNA structure, tubulin positioning for nuclear polarity and nuclear membrane proteins of tumor cells.
Area of Expertise and Interests:
A. Diagnostic pathology field:
1) Analyses of clinicopathological characteristics of various human diseases,
particularly in thyroid, genitourinary tracts and skin.
2) Pattern recognition analysis of human tumors according to algorithmic and logical
methods for histocytological findings.
B. Basic pathology field:
1) Molecular background of structural and cellular atypia of tumors.
i) morphological analysis of tumor cell nuclei related with cell cycle.
ii) analysis of nuclear membrane proteins of tumor cells.
iii) conservation and alteration of chromosome territories in tumor cell nuclei.
iv) analysis of intracellular tubulin positioning for nuclear polarity.
2) Application of digital image analysis such as texture analysis to histocytochemistry.
3) Quantitative histocytochemical analysis of using fluorescence properties.
4) In situ visualization of point mutation of human tumor cells.
Our research policy
FINER criteria (Cummings SR, et al 2001): Feasible, Interesting, Novel,
Ethical, Relevant
Contact
Professor & Chairman; Shin-ichi Murata, MD, Ph.D.
Department of Human Pathology, Wakayama Medical University
(Department of Diagnostic Pathology, Wakayama Medical University Hospital)
811-1 Kimiidera, Wakayama 641-8509, Japan
Contact E-mail; w-hupath@wakayama-med.ac.jp
和歌山県立医科大学人体病理学教室
〒641-8509
和歌山市紀三井寺811-1 アクセス
TEL 073-441-0635
FAX 073-444-5777
w-hupath@wakayama-med.ac.jp
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